| 11 Jul | Real Madrid – Fuenlabrada | Friendly · Preseson match | 3–1 |
| 18 Jul | Rayo Vallecano – Real Madrid | Friendly · PreSeason 2021/22 | 1–1 |
| 25 Jul | Rangers – Real Madrid | Friendly · PreSeason 2021/22 | 2–1 |
| 8 Aug | Milan – Real Madrid | Friendly · PreSeason 2021/22 | 0–0 |
| 14 Aug | Dep. Alavés – Real Madrid | La Liga · La Liga - Matchday 1 | 1–4 |
| 22 Aug | Levante Unión Deportiva – Real Madrid | La Liga · La Liga - Matchday 2 | 3–3 |
| 28 Aug | Real Betis – Real Madrid | La Liga · La Liga - Matchday 3 | 0–1 |
| 12 Sep | Real Madrid – Celta de Vigo | La Liga · La Liga - Matchday 4 | 5–2 |
| 15 Sep | Inter Milan – Real Madrid | Champions League · Group play - Leg 1 | 0–1 |
| 19 Sep | Valencia – Real Madrid | La Liga · La Liga - Matchday 5 | 1–2 |
| 22 Sep | Real Madrid – Mallorca | La Liga · La Liga - Matchday 6 | 6–1 |
| 25 Sep | Real Madrid – Villarreal | La Liga · La Liga - Matchday 7 | 0–0 |
| 28 Sep | Real Madrid – Sheriff Tiraspol | Champions League · Group play - Leg 2 | 1–2 |
| 3 Oct | Espanyol – Real Madrid | La Liga · La Liga - Matchday 8 | 2–1 |
| 19 Oct | Shakhtar Donetsk – Real Madrid | Champions League · Group play - Leg 3 | 0–5 |
| 24 Oct | Barcelona – Real Madrid | La Liga · La Liga - Matchday 10 | 1–2 |
| 27 Oct | Real Madrid – Osasuna | La Liga · La Liga - Matchday 11 | 0–0 |
| 31 Oct | Elche – Real Madrid | La Liga · La Liga - Matchday 12 | 1–2 |
| 3 Nov | Real Madrid – Shakhtar Donetsk | Champions League · Group play - Leg 4 | 2–1 |
| 6 Nov | Real Madrid – Rayo Vallecano | La Liga · La Liga - Matchday 13 | 2–1 |
| 21 Nov | Granada – Real Madrid | La Liga · La Liga - Matchday 14 | 1–4 |
| 24 Nov | Sheriff Tiraspol – Real Madrid | Champions League · Group play - Leg 5 | 0–3 |
| 28 Nov | Real Madrid – Sevilla | La Liga · La Liga - Matchday 15 | 2–1 |
| 1 Dec | Real Madrid – Athletic Bilbao | La Liga · La Liga - Matchday 9 | 1–0 |
| 4 Dec | Real Sociedad – Real Madrid | La Liga · La Liga - Matchday 16 | 0–2 |
| 7 Dec | Real Madrid – Inter Milan | Champions League · Group play - Leg 6 | 2–0 |
| 12 Dec | Real Madrid – Atletico Madrid | La Liga · La Liga - Matchday 17 | 2–0 |
| 19 Dec | Real Madrid – Cadiz | La Liga · La Liga - Matchday 18 | 0–0 |
| 22 Dec | Athletic Bilbao – Real Madrid | La Liga · La Liga - Matchday 21 | 1–2 |
| 2 Jan | Getafe – Real Madrid | La Liga · La Liga - Matchday 19 | 1–0 |
| 5 Jan | Alcoyano – Real Madrid | Copa del Rey · Round of 32 | 1–3 |
| 8 Jan | Real Madrid – Valencia | La Liga · La Liga - Matchday 20 | 4–1 |
| 13 Jan | Barcelona – Real Madrid | Supercopa · Semifinal | 2–3 |
| 16 Jan | Athletic Bilbao – Real Madrid | Supercopa · Final | 0–2 |
| 20 Jan | Elche – Real Madrid | Copa del Rey · Round of 16. | 1–2 |
| 23 Jan | Real Madrid – Elche | La Liga · La Liga - Matchday 22 | 2–2 |
| 3 Feb | Athletic Bilbao – Real Madrid | Copa del Rey · Quiarterfinal | 1–0 |
| 6 Feb | Real Madrid – Granada | La Liga · La Liga - Matchday 23 | 1–0 |
| 13 Feb | Villarreal – Real Madrid | La Liga · La Liga - Matchday 24 | 0–0 |
| 15 Feb | Paris Saint Germain – Real Madrid | Champions League · Round of 16 - Leg 1 | 1–0 |
| 19 Feb | Real Madrid – Dep. Alavés | La Liga · La Liga - Matchday 25 | 3–0 |
| 26 Feb | Rayo Vallecano – Real Madrid | La Liga · La Liga - Matchday 26 | 0–1 |
| 5 Mar | Real Madrid – Real Sociedad | La Liga · La Liga - Matchday 27 | 4–1 |
| 9 Mar | Real Madrid – Paris Saint Germain | Champions League · Round of 16 - Leg 2 | 3–1 |
| 14 Mar | Mallorca – Real Madrid | La Liga · La Liga - Matchday 28 | 0–3 |
| 20 Mar | Real Madrid – Barcelona | La Liga · La Liga - Matchday 29 | 0–4 |
| 3 Apr | Celta de Vigo – Real Madrid | La Liga · La Liga - Matchday 30 | 1–2 |
| 5 Apr | Chelsea – Real Madrid | Champions League · Quarter final - Leg 1 | 1–3 |
| 9 Apr | Real Madrid – Getafe | La Liga · La Liga - Matchday 31 | 2–0 |
| 12 Apr | Real Madrid – Chelsea | Champions League · Quarter final - Leg 2 | 2–3 |
| 17 Apr | Sevilla – Real Madrid | La Liga · La Liga - Matchday 32 | 2–3 |
| 20 Apr | Osasuna – Real Madrid | La Liga · La Liga - Matchday 33 | 1–3 |
| 26 Apr | Manchester City – Real Madrid | Champions League · Semi Final - Leg 1 | 4–3 |
| 30 Apr | Real Madrid – Espanyol | La Liga · La Liga - Matchday 34 | 4–0 |
| 4 May | Real Madrid – Manchester City | Champions League · Semi Final - Leg 2 | 3–1 |
| 8 May | Atletico Madrid – Real Madrid | La Liga · La Liga - Matchday 35 | 1–0 |
| 12 May | Real Madrid – Levante Unión Deportiva | La Liga · La Liga - Matchday 36 | 6–0 |
| 15 May | Cadiz – Real Madrid | La Liga · La Liga - Matchday 37 | 1–1 |
| 22 May | Real Madrid – Real Betis | La Liga · La Liga - Matchday 38 | 0–0 |
| 28 May | Real Madrid – Liverpool | Champions League · Final | 1–0 |