The Liga champions will be hoping star man Cristiano Ronaldo can put aside his apparent misery and fire his team to three points in the Andalusian capital.
Sevilla welcome back midfielder Diego Perotti from injury for Saturday's clash with Real Madrid at the Ramon Sanchez Pizjuan.
But the Andalusian outfit are set to be without Jose Antonio Reyes, who missed the goalless draw at Rayo Vallecano with a shoulder problem.
Goalkeeper Diego Lopez returns from suspension, while French midfielder Geoffrey Kondogbia may be given his debut.
Real Madrid have no fresh injury concerns, with the suspended Fabio Coentrao being the only absentee.
Cristiano Ronaldo is expected to start despite his apparent dissatisfaction with the Madrid hierarchy.